翻訳と辞書 Words near each other ・ Methyl phenkapton ・ Methyl phenylacetate ・ Methyl propionate ・ Methyl radical ・ Methyl red ・ Methyl salicylate ・ Methyl tert-butyl ether ・ Methyl thiocyanate ・ Methyl trifluoromethansulfonate ・ Methyl vinyl ether ・ Methyl vinyl ketone ・ Methyl violet ・ Methyl yellow ・ Methyl-1-testosterone ・ Methyl-accepting chemotaxis protein ・ Methyl-CpG-binding domain ・ Methyl-CpG-binding domain protein 2 ・ Methyl-DMA ・ Methyl-DOB ・ Methyl-MMDA-2 ・ Methyl-n-amylnitrosamine ・ Methyl-ONN-azoxymethanol beta-D-glucosyltransferase ・ Methyl-α-D-galactose ・ Methylacetylene-propadiene gas ・ Methylacrylate ・ Methylaluminoxane ・ Methylamide ・ Methylamine ・ Methylamine dehydrogenase (amicyanin) ・ Methylamine-corrinoid protein Co-methyltransferase Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Methyl-CpG-binding domain ： ウィキペディア英語版 Methyl-CpG-binding domain The Methyl-CpG-binding domain (MBD) in molecular biology binds to DNA that contains one or more symmetrically methylated CpGs. MBD has negligible non-specific affinity for unmethylated DNA. In vitro foot-printing with the chromosomal protein MeCP2 showed that the MBD could protect a 12 nucleotide region surrounding a methyl CpG pair.〔 DNA methylation at CpG dinucleotides, the most common DNA modification in eukaryotes, has been associated with various phenomena such as alterations in chromatin structure, genomic imprinting, transposon and chromosome X inactivation, differentiation, and cancer. Effects of DNA methylation are mediated through proteins that bind to symmetrically methylated CpGs. Such proteins contain a specific domain of ~70 residues, the methyl-CpG-binding domain (MBD), which is linked to additional domains associated with chromatin, such as the bromodomain, the AT hook motif, the SET domain, or the PHD finger. MBD-containing proteins appear to act as structural proteins, which recruit a variety of histone deacetylase (HDAC) complexes and chromatin remodelling factors, leading to chromatin compaction and, consequently, to transcriptional repression. The MBD of MeCP2, MBD1, MBD2, MBD4 and BAZ2 mediates binding to DNA, and in cases of MeCP2, MBD1 and MBD2, preferentially to methylated CpG. In human MBD3 and SETDB1, the MBD has been shown to mediate protein-protein interactions. MBDs are also found in DNA demethylase. The MBD folds into an alpha/beta sandwich structure comprising a layer of twisted beta sheet, backed by another layer formed by the alpha1 helix and a hairpin loop at the C terminus. These layers are both amphipathic, with the alpha1 helix and the beta sheet lying parallel and the hydrophobic faces tightly packed against each other. The beta sheet is composed of two long inner strands (beta2 and beta3) sandwiched by two shorter outer strands (beta1 and beta4). ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Methyl-CpG-binding domain」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.